A new study has unveiled strong evidence linking early menopause to an elevated risk of depression among certain women. Published in the journal *Menopause*, the research sheds light on the psychological challenges faced by women diagnosed with premature menopause, also known as premature or primary ovarian insufficiency (POI), before the age of 40.Premature menopause occurs when the ovaries cease to function properly, leading to a significant loss of oestrogen production and reproductive capability. This condition not only triggers physical symptoms but can also induce a profound psychological impact, manifesting in various mental health issues, particularly depression and anxiety.Risk Factors for DepressionThe study examined 345 women with diagnoses of POI and found that approximately 29.9 per cent exhibited symptoms of depression. Key risk factors identified included a younger age at diagnosis, the severity of menopausal symptoms, a lack of emotional support, and grief related to fertility loss. Dr. Monica Christmas, the associate medical director for The Menopause Society, emphasised the crucial need for regular screening for depressive symptoms in this vulnerable group. "The high prevalence of depressive symptoms in those with POI highlights the importance of routine screening in this vulnerable population," she stated. Dr. Christmas further noted that addressing mental health concerns with evidence-based interventions should be integral to comprehensive management plans for women suffering from POI. Hormone Therapy and Its LimitationsDespite perception, the research revealed no significant difference in depressive symptoms between women undergoing hormone therapy with oestrogen and progestogen and those not receiving such treatment. Dr. Christmas clarified that although hormone therapy is a standard approach to managing some symptoms of menopause, it is not considered a primary treatment for mood disorders. She remarked, "This was evident in this study where there was no difference in depressive symptoms between those using hormones and those not using hormone therapy."The findings from this study underscore the complex interplay between physical health and mental wellbeing in women undergoing early menopause. As healthcare providers work to enhance treatment plans for POI, mental health support must be considered a priority.As discussions surrounding menopause continue to evolve, this research adds to the growing body of evidence that highlights not only the physical ramifications of premature menopause but also the significant emotional toll it can take on women's lives. In conclusion, raising awareness and improving support systems for women experiencing early menopause may contribute to better overall outcomes. With further research and dedicated resources, the healthcare community can aim to address both the physiological and psychological needs of women facing this challenging transition.